Long-lasting cross-presentation of tumor antigen in human DC
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چکیده
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a cross-comparative dtudy between two textbook series in terms of the presentation of politeness
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15 صفحه اولMeasles virus vaccine-infected tumor cells induce tumor antigen cross-presentation by human plasmacytoid dendritic cells.
PURPOSE Plasmacytoid dendritic cells (pDC) are antigen-presenting cells specialized in antiviral response. The measles virus vaccine is proposed as an antitumor agent to target and specifically kill tumor cells without infecting healthy cells. EXPERIMENTAL DESIGN Here, we investigated, in vitro, the effects of measles virus vaccine-infected tumor cells on the phenotype and functions of human ...
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Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigenderived peptides are presented on MHC I molecules to cytotoxic T cells. Cross-presentation has been shown to be of crucial ...
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The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these receptors in vivo has not been explored in depth. Using a spleen efferocytosis assay and targeted genetic deletion in mice, we identified a multiprotein complex--composed of ...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2009
ISSN: 0014-2980
DOI: 10.1002/eji.200838669